I didn’t get any vaccinations for this trip. I have had them all in 2017-18.
Make sure you are up-to-date on routine vaccines before every trip. These vaccines include measles-mumps-rubella (MMR), diphtheria-tetanus-pertussis, varicella (chickenpox), polio vaccine, and your yearly flu shot.
The US CDC has vaccine recommendations, I did not get any besides the above for my trip in 2016-17.
Wash your hands, wash your veggies and all fruit before eating or cooking—some clean the veggies in a chlorine sterilant. You can find it in the vegetable department of the Supermercado.
Just like in the USA do not drink water from rivers, streams, and lakes, you must boil or purify it.
City and town tap water is just fine in Chile.
I have found that the restaurants in Chile are fine but street food is questionable. I am going to update this statement as of 11/17/2017, some restaurants are ok. I had an event that may have been caused by a meal last Sunday, it could have been the seeds I ate or the meal, I cannot say but I got a little bit sick.